Saxenda contains liraglutide as its active ingredient, a synthetic analog of the human glucagon-like peptide-1 (GLP-1) hormone. GLP-1 is naturally released in the body after meals and plays a vital role in regulating appetite, glucose metabolism, and insulin secretion.
When administered as a medication, liraglutide acts as a GLP-1 receptor agonist, meaning it binds to and activates the GLP-1 receptors in the body. This activation leads to several physiological effects that contribute to weight loss:
- Appetite Suppression: One of the key mechanisms by which Saxenda promotes weight loss is by reducing appetite. Liraglutide activates the GLP-1 receptors in the hypothalamus, the region of the brain responsible for regulating hunger and satiety. By stimulating these receptors, Saxenda signals the brain to feel full, resulting in reduced food intake and decreased cravings.
- Delayed Gastric Emptying: Saxenda also slows down the emptying of the stomach, leading to a prolonged feeling of fullness and reduced hunger. This delayed gastric emptying helps individuals consume fewer calories, contributing to weight loss.
- Blood Sugar Regulation: Another important effect of Saxenda is its ability to regulate blood sugar levels. By activating GLP-1 receptors in the pancreas, liraglutide enhances insulin secretion in response to elevated blood sugar levels. This action helps improve glucose control and may be beneficial for individuals with type 2 diabetes or prediabetes.
- Weight Loss Promotion: Saxenda's multifaceted approach to weight loss extends beyond appetite suppression and blood sugar regulation. It also enhances the breakdown of stored fat and reduces the production of glucose by the liver. These mechanisms further contribute to weight loss and improvements in body composition.